Rev Iberoam Micol
2008; 25:50-51.
Isolated lymphadenitis due to Histoplasma capsulatum diagnosed by fine-needle aspiration biopsy and immunohistochemistryFelipe F. Tuon, Vivian Gomes, Carla Pagliari, Bruno B. Ctenas, Patrícia Carrasco Flores de Moscoso, René Gerhard, Luciane Kanashiro, Roosecelis A. Brasil & Maria Irma Seixas DuarteDepartment of Infectious Diseases, University of Sao Paulo, São Paulo, BrasilIn the disseminated form of histoplasmosis, isolation and further identification of Histoplasma capsulatum can be performed by several methods, namely, bone marrow aspiration, blood culture, and liver biopsy. Lymph node disease usually is diagnosed by excisional biopsy. Although fungal stains can identify this fungus, detection of specific antigens by immunohistochemistry shows a higher specificity and sensitivity. This approach can use the cell block method when the material is not sent to fungal cultures or fresh staining. 
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